The aim of this work was to determine the antibiotic susceptibility pattern of the Staphylococcus aureus\nisolates from orthopaedic patients and their plasmid carriage. A total number of 39 S. aureus were\nisolated from wound, skin and bed of orthopaedic patients in Ahmadu Bello University Teaching\nHospital Zaria, Nigeria with the use of API STAPH identification kit. Antibiotics susceptibility test was\ndone using disc agar diffusion test, plasmid analysis was also carried out. A high percentage (97.4%) of\nthe S. aureus isolates were susceptible to both vancomycin and gentamicin followed by ciprofloxacin\n(94.9%) and pefloxacin (84.6%). The S. aureus isolates were highly resistant to the following antibiotics:\nampicilin (94.9%), ceftriaxone (79.5%), cefoxitin (64.1%) and amoxicillin - clavulanic acid (59%). The\nantibiotic susceptibility tests showed that 29.4% of S. aureus with plasmids were multi-drug resistant\nbeing resistant to three or more classes of antibiotics. In the plasmid analysis 60.7% of the S. aureus\nisolates had plasmids with size range 9.2 to 13.3 kb. Plasmid-coded antibiotic resistance encompasses\nmost classes of antibiotics commonly used at the forefront of clinical antibiotic therapy.
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